IMPROVE-IT clinical implications. Should the "high-intensity cholesterol-lowering therapy" strategy replace the "high-intensity statin therapy"?
نویسندگان
چکیده
a Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, “Sant Joan” University Hospital, Universitat Rovira i Virgili, IISPV, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain b Lipid and Vascular Risk Unit, Hospital del Mar, Universitat Aut onoma de Barcelona, Barcelona, Spain c Head Lipid Unit, Hospital Universitario Miguel Servet, IIS Aragon, Red Cardiovascular Research Network (RIC), Zaragoza, Spain
منابع مشابه
Effectiveness of combination therapy with statin and another lipid-modifying agent compared with intensified statin monotherapy.
BACKGROUND Some patients do not tolerate or respond to high-intensity statin monotherapy. Lower-intensity statin combined with nonstatin medication may be an alternative, but the benefits and risks compared with those of higher-intensity statin monotherapy are unclear. PURPOSE To compare the clinical benefits, adherence, and harms of lower-intensity statin combination therapy with those of hi...
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Large controlled clinical trials have demonstrated reductions with statin therapy in cardiovascular events in patients presenting with acute coronary syndromes and stable coronary heart disease and individuals at high risk of a cardiovascular event. In trials of acute coronary syndromes and stable coronary heart disease, high-intensity statin therapy is more effective in the prevention of recur...
متن کاملUse of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients
Background. In clinical practice, most coronary artery disease patients are not achieving their recommend LDL-cholesterol goal of <70 mg/dL. Methods. We conducted a retrospective analysis of outpatient electronic health records and the most recent lipid profile, lipid-lowering medications and doses were collected. Results. We identified 9950 coronary artery disease patients. Only 37% on a stati...
متن کاملStatin therapy for stroke prevention.
BACKGROUND AND PURPOSE Statins are widely used to reduce the risk of stroke in patients with coronary artery disease (CAD), but less so in patients without CAD. We reviewed recent trials for new evidence for the reduction in risk of stroke. SUMMARY OF REVIEW In patients with CAD, moderate-intensity statin treatment has been associated with reductions in risk of stroke, with no increase in hem...
متن کاملImplications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.
The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management in 2001. Since the publication of ATP III, 5 major clinical trials of statin therapy with clinical end points have been published. These trials addressed issues that were not examined in previous clinical trials of cholesterol-lowering therap...
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ورودعنوان ژورنال:
- Atherosclerosis
دوره 240 1 شماره
صفحات -
تاریخ انتشار 2015